In Vivo Screening Data Summary

NCI In Vivo Screening Data

Lewis Lung Carcinoma (intramuscular) in C57BL/6 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX011 (ip) median survival time other 5.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 10.0 mg/kg/injection 88.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 45; 05/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) median survival time other 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 5.0 mg/kg/injection 62.0 Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 10.0 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 12; 07/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 05/08 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight other 40.0 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 12; 08/08 animals surviving on tox evaluation day (usually day 5)