In Vivo Screening Data Summary

NCI In Vivo Screening Data

Lewis Lung Carcinoma (intrathoracic) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time alkali diluted with saline 3.75 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 7.5 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on day 6
Q01DX009 (ip) median survival time alkali diluted with saline 7.5 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 15.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on day 6
Q01DX009 (ip) median survival time alkali diluted with saline 15.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 30.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 6
Q01DX009 (ip) median survival time alkali diluted with saline 30.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 60.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 6
Q01DX009 (ip) median survival time alkali diluted with saline 60.0 mg/kg/injection 119.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5