| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.5 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 5.0 mg/kg/injection | 130.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 5.0 mg/kg/injection | 116.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 8.0 mg/kg/injection | 112.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 9.8 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 9.8 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 90; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 10.0 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 10.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 10.0 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 14.0 mg/kg/injection | 163.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 14.0 mg/kg/injection | 126.0 | Antitumor endpoint evaluated on day 90; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 16.0 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 20.0 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 20.0 mg/kg/injection | 135.0 | Antitumor endpoint evaluated on day 90; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 20.0 mg/kg/injection | 186.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 20.0 mg/kg/injection | 127.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 20.0 mg/kg/injection | 123.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 28.6 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 28.6 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 32.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 40.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 40.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 40.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 40.9 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 40.9 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 80.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 80.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX022 (ip) | median survival time | saline | 6.9 mg/kg/injection | 139.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX022 (ip) | median survival time | saline | 9.8 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX022 (ip) | median survival time | saline | 14.0 mg/kg/injection | 193.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX022 (ip) | median survival time | saline | 20.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q01DX022 (ip) | median survival time | saline | 28.6 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 7.5 mg/kg/injection | 96.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 7.5 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 7.5 mg/kg/injection | 96.0 | Antitumor endpoint evaluated on day 60; 06/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 15.0 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 15.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 15.0 mg/kg/injection | 110.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 107.0 | Antitumor endpoint evaluated on day 90; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 20.0 mg/kg/injection | 102.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 30.0 mg/kg/injection | 115.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 30.0 mg/kg/injection | 109.0 | Antitumor endpoint evaluated on day 90; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 30.0 mg/kg/injection | 139.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 30.0 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 30.0 mg/kg/injection | 115.0 | Antitumor endpoint evaluated on day 60; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 30.0 mg/kg/injection | 105.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 30.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 30.0 mg/kg/injection | 115.0 | Antitumor endpoint evaluated on day 60; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 44.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 44.0 mg/kg/injection | 114.0 | Antitumor endpoint evaluated on day 90; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 44.0 mg/kg/injection | 206.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 44.0 mg/kg/injection | 114.0 | Antitumor endpoint evaluated on day 60; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 44.0 mg/kg/injection | 114.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 60.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 06/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 60.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 05/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 60.0 mg/kg/injection | 150.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 67.0 mg/kg/injection | 100.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 67.0 mg/kg/injection | 136.0 | Antitumor endpoint evaluated on day 90; 06/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 67.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 67.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 67.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 100.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 100.0 mg/kg/injection | 122.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 100.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 100.0 mg/kg/injection | 125.0 | Antitumor endpoint evaluated on day 90; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 100.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 120.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 120.0 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 60; 07/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX003 (ip) | median survival time | saline | 120.0 mg/kg/injection | 131.0 | Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX006 (ip) | median survival time | saline | 13.2 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX006 (ip) | median survival time | saline | 20.0 mg/kg/injection | 135.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX006 (ip) | median survival time | saline | 30.0 mg/kg/injection | 140.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX006 (ip) | median survival time | saline | 44.0 mg/kg/injection | 145.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX006 (ip) | median survival time | saline | 67.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |
| Q04DX006 (ip) | median survival time | saline | 100.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 90; 08/08 animals surviving on tox evaluation day (usually day 5) |