In Vivo Screening Data Summary

NCI In Vivo Screening Data

Lewis Lung Carcinoma (intravenous) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 60; 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 122.0 Antitumor endpoint evaluated on day 60; 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 60; 03/04 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 60; 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 240.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 60; 04/04 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 7.5 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 87.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 240.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)