In Vivo Screening Data Summary

NCI In Vivo Screening Data

Lewis Lung Carcinoma (intravenous) in B6C3F1 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 15.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 30.0 mg/kg/injection 116.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 60.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 240.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 60; 07/10 animals surviving on tox evaluation day (usually day 5)