| Schedule (route) | Endpoint | Vehicle | Dose | Treated/Control (%) | Observations |
|---|---|---|---|---|---|
| Q01DX000 (ip) | median survival time | alkali diluted with saline | 0.3 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 16; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX000 (ip) | median survival time | alkali diluted with saline | 3.0 mg/kg/injection | 101.0 | Antitumor endpoint evaluated on day 16; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX000 (ip) | median survival time | alkali diluted with saline | 30.0 mg/kg/injection | 97.0 | Antitumor endpoint evaluated on day 16; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 1.0 mg/kg/injection | 106.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 2.0 mg/kg/injection | 121.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 4.0 mg/kg/injection | 117.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 8.0 mg/kg/injection | 121.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 16.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline | 32.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 15.0 mg/kg/injection | 141.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 15.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 15.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 30.0 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 30.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/09 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 30.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 60.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 60.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 60.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 120.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 120.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | Klucel (hydroxypropylcellulose) (HPC) | 120.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 15.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 15.0 mg/kg/injection | 108.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 30.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 30.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 60.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 60.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 120.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median survival time | saline with Tween-80 | 120.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 60; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 15.0 mg/kg/injection | 79.0 | Antitumor endpoint evaluated on day 18; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 30.0 mg/kg/injection | 72.0 | Antitumor endpoint evaluated on day 18; 07/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX009 (ip) | median tumor weight (est.) | saline with Tween-80 | 60.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 18; 04/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | alkali diluted with saline | 10.0 mg/kg/injection | 98.0 | Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | alkali diluted with saline | 20.0 mg/kg/injection | 91.0 | Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | alkali diluted with saline | 40.0 mg/kg/injection | 89.0 | Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median survival time | alkali diluted with saline | 80.0 mg/kg/injection | 0.0 | Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | alkali diluted with saline | 5.0 mg/kg/injection | 58.0 | Antitumor endpoint evaluated on day 12; 09/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | alkali diluted with saline | 10.0 mg/kg/injection | 60.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | alkali diluted with saline | 12.5 mg/kg/injection | 62.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | alkali diluted with saline | 20.0 mg/kg/injection | 51.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | alkali diluted with saline | 25.0 mg/kg/injection | 66.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | mean tumor weight | alkali diluted with saline | 50.0 mg/kg/injection | 62.0 | Antitumor endpoint evaluated on day 12; 08/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 10.0 mg/kg/injection | 153.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 10.0 mg/kg/injection | 132.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on day 12 |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 10.0 mg/kg/injection | 82.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on day 12 |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 20.0 mg/kg/injection | 82.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 20.0 mg/kg/injection | 73.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on day 12 |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 20.0 mg/kg/injection | 113.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on day 12 |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 35.0 mg/kg/injection | 44.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on day 12 |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 40.0 mg/kg/injection | 104.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 40.0 mg/kg/injection | 60.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on day 12 |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 40.0 mg/kg/injection | 79.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on day 12 |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 51.0 mg/kg/injection | 38.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on day 12 |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 80.0 mg/kg/injection | 75.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on tox evaluation day (usually day 5) |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 80.0 mg/kg/injection | 70.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on day 12 |
| Q01DX011 (ip) | median tumor weight (est.) | alkali diluted with saline | 80.0 mg/kg/injection | 93.0 | Antitumor endpoint evaluated on day 12; 10/10 animals surviving on day 12 |