In Vivo Screening Data Summary

NCI In Vivo Screening Data

Lewis Lung Carcinoma (subcutaneous) in C57BL/6 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX011 (ip) mean tumor weight alkali diluted with saline 12.5 mg/kg/injection 71.0 Antitumor endpoint evaluated on day 12; 12/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight alkali diluted with saline 25.0 mg/kg/injection 61.0 Antitumor endpoint evaluated on day 12; 12/12 animals surviving on tox evaluation day (usually day 5)
Q01DX011 (ip) mean tumor weight alkali diluted with saline 50.0 mg/kg/injection 71.0 Antitumor endpoint evaluated on day 12; 12/12 animals surviving on tox evaluation day (usually day 5)