In Vivo Screening Data Summary

NCI In Vivo Screening Data

Human Amelanotic Melanoma (LOX) (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 3088
CAS 305-03-3
Chlorambucil; Leukeran; Ambochlorin

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q02DX002 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 0.13 mg/kg/injection 85.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 0.2 mg/kg/injection 73.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 0.3 mg/kg/injection 75.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.0 mg/kg/injection 41.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 18.0 mg/kg/injection 36.0 Antitumor endpoint evaluated on day 6; 06/06 animals surviving on day 6
Q02DX002 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 27.0 mg/kg/injection 59.0 Antitumor endpoint evaluated on day 6; 05/06 animals surviving on day 6