In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to 6-MMPR; NSC 40774 (intraperitoneal) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX005 (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 88.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX005 (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX005 (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 30; 07/08 animals surviving on day 5
Q01DX005 (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX005 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX005 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX005 (ip) mean survival time alkali diluted with saline 80.0 mg/kg/injection 88.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX005 (ip) mean survival time alkali diluted with saline 80.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX005 (ip) mean survival time alkali diluted with saline 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/08 animals surviving on day 5
Q01DX005 (ip) mean survival time alkali diluted with saline 160.0 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5