In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to A Terephthalanilide; NSC 38280 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (ip) mean survival time alkali diluted with saline 5.0 mg/kg/injection 98.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 5.0 mg/kg/injection 108.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 5.0 mg/kg/injection 120.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 5.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 103.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 115.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 118.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 115.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 114.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 126.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 125.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 134.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 136.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 148.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 135.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 80.0 mg/kg/injection 131.0 Experiment continued until the death of all animals; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 80.0 mg/kg/injection 161.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 80.0 mg/kg/injection 128.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 80.0 mg/kg/injection 143.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 2.5 mg/kg/injection 120.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 5.0 mg/kg/injection 138.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 7.5 mg/kg/injection 165.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 10.0 mg/kg/injection 172.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 12.5 mg/kg/injection 156.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 25.0 mg/kg/injection 152.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 50.0 mg/kg/injection 140.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 62.5 mg/kg/injection 120.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 100.0 mg/kg/injection 107.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 125.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 250.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 03/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 500.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 00/06 animals surviving on tox evaluation day (usually day 5)