In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to Methotrexate; NSC 740 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 3088
CAS 305-03-3
Chlorambucil; Leukeran; Ambochlorin

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 1.0 mg/kg/injection 105.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 2.0 mg/kg/injection 97.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 4.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 5.0 mg/kg/injection 103.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 6.25 mg/kg/injection 107.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 12.5 mg/kg/injection 95.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 25.0 mg/kg/injection 90.0 Experiment continued until the death of all animals; 04/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 50.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 00/06 animals surviving on tox evaluation day (usually day 5)