In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to Methotrexate; NSC 740 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (ip) mean survival time alkali diluted with saline 5.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 99.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 101.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 104.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 80.0 mg/kg/injection 95.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 1.2 mg/kg/injection 118.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 2.4 mg/kg/injection 91.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 3.0 mg/kg/injection 95.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 6.0 mg/kg/injection 111.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 9.0 mg/kg/injection 95.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 12.0 mg/kg/injection 98.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 24.0 mg/kg/injection 130.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 36.0 mg/kg/injection 102.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 25.0 mg/kg/injection 103.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 25.0 mg/kg/injection 93.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 50.0 mg/kg/injection 106.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 50.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 02/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 50.0 mg/kg/injection 98.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 50.0 mg/kg/injection 92.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 50.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 00/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 100.0 mg/kg/injection 98.0 Experiment continued until the death of all animals; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 100.0 mg/kg/injection 123.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 100.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 00/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time alkali diluted with saline 5.0 mg/kg/injection 91.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time alkali diluted with saline 5.0 mg/kg/injection 120.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time alkali diluted with saline 5.0 mg/kg/injection 102.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 94.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 125.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 110.0 Experiment continued until the death of all animals; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 102.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 117.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 91.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)