In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to Methotrexate; NSC 740 (subcutaneous) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX Z (sc) median survival time other 14.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 23.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 40; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 39.0 mg/kg/injection 120.0 Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 65.0 mg/kg/injection 150.0 Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 108.0 mg/kg/injection 150.0 Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (sc) median survival time other 180.0 mg/kg/injection 130.0 Antitumor endpoint evaluated on day 40; 10/10 animals surviving on tox evaluation day (usually day 5)