In Vivo Screening Data Summary

NCI In Vivo Screening Data

MPC-2 Plasma Cell (subcutaneous) in unknown mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX005 (ip) mean tumor weight other 6.25 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 16; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight other 12.5 mg/kg/injection 70.0 Antitumor endpoint evaluated on day 16; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight other 25.0 mg/kg/injection 65.0 Antitumor endpoint evaluated on day 16; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight other 50.0 mg/kg/injection 47.0 Antitumor endpoint evaluated on day 16; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) mean tumor weight other 100.0 mg/kg/injection 41.0 Antitumor endpoint evaluated on day 16; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 6.25 mg/kg/injection 19.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 6.25 mg/kg/injection 21.0 Antitumor endpoint evaluated on day 14; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 6.25 mg/kg/injection 30.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 12.5 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 12.5 mg/kg/injection 32.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 14.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 25.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 14; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 50.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 00/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 50.0 mg/kg/injection 21.0 Antitumor endpoint evaluated on day 14; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean tumor weight other 100.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 14; 00/10 animals surviving on tox evaluation day (usually day 5)