In Vivo Screening Data Summary

NCI In Vivo Screening Data

Sarcoma M5076 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX005 (ip) median survival time alkali diluted with saline 20.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 100; 08/08 animals surviving on day 17
Q04DX005 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 131.0 Antitumor endpoint evaluated on day 100; 07/08 animals surviving on day 17
Q04DX005 (ip) median survival time alkali diluted with saline 80.0 mg/kg/injection 120.0 Antitumor endpoint evaluated on day 100; 08/08 animals surviving on day 17
Q04DX005 (ip) median survival time alkali diluted with saline 160.0 mg/kg/injection 141.0 Antitumor endpoint evaluated on day 100; 08/08 animals surviving on day 17
Q04DX005 (ip) median survival time alkali diluted with saline 320.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 100; 07/08 animals surviving on day 17