In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to Methyl-GAG; NSC 32946 (subcutaneous) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX Z (ip) mean survival time other 12.5 mg/kg/injection 107.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 12.5 mg/kg/injection 145.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 18.75 mg/kg/injection 128.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 25.0 mg/kg/injection 125.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 25.0 mg/kg/injection 133.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 37.5 mg/kg/injection 252.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 50.0 mg/kg/injection 153.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 50.0 mg/kg/injection 192.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 75.0 mg/kg/injection 157.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 100.0 mg/kg/injection 128.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 100.0 mg/kg/injection 164.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 150.0 mg/kg/injection 126.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 200.0 mg/kg/injection 97.0 Experiment continued until the death of all animals; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 200.0 mg/kg/injection 119.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time other 300.0 mg/kg/injection 98.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)