In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to 6-MP & 6-Thioguanine; NSC 755, NSC 752 (intracerebral) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 45; 08/09 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 50.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 50.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on day 5