In Vivo Screening Data Summary

NCI In Vivo Screening Data

L1210 Leukemia resistant to 6-MP & 6-Thioguanine; NSC 755, NSC 752 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 40.0 mg/kg/injection 102.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 40.0 mg/kg/injection 109.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 59.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 60.0 mg/kg/injection 108.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 90.0 mg/kg/injection 102.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 90.0 mg/kg/injection 99.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 91.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 91.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 91.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 91.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 91.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 91.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 135.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 135.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 135.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 135.0 mg/kg/injection 87.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 135.0 mg/kg/injection 99.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 135.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 135.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 135.0 mg/kg/injection 105.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 150.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time carboxymethylcellulose (CMC) 203.0 mg/kg/injection 95.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 26.0 mg/kg/injection 97.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 26.0 mg/kg/injection 101.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 98.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 98.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 60.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 60.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 60.0 mg/kg/injection 106.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 90.0 mg/kg/injection 97.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 90.0 mg/kg/injection 103.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 90.0 mg/kg/injection 87.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 135.0 mg/kg/injection 103.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 135.0 mg/kg/injection 105.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 135.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 202.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 202.0 mg/kg/injection 102.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) mean survival time alkali diluted with saline 202.0 mg/kg/injection 99.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 60.0 mg/kg/injection 94.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) mean survival time alkali diluted with saline 80.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 5.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 45; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 5.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 8.0 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 8.0 mg/kg/injection 103.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 8.0 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 12.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 12.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 12.0 mg/kg/injection 90.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 16.0 mg/kg/injection 95.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 18.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 18.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 20.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 24.0 mg/kg/injection 93.0 Experiment continued until the death of all animals; 09/09 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 27.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 27.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 40.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time carboxymethylcellulose (CMC) 40.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 45; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time alkali diluted with saline 10.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time alkali diluted with saline 20.0 mg/kg/injection 103.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX015 (ip) mean survival time alkali diluted with saline 40.0 mg/kg/injection 103.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 3.5 mg/kg/injection 99.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 7.0 mg/kg/injection 100.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 7.0 mg/kg/injection 106.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 7.0 mg/kg/injection 103.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 12.0 mg/kg/injection 110.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 12.5 mg/kg/injection 95.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 14.0 mg/kg/injection 104.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 14.0 mg/kg/injection 96.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 14.0 mg/kg/injection 98.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 19.0 mg/kg/injection 123.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 20.0 mg/kg/injection 101.0 Experiment continued until the death of all animals; 05/05 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 25.0 mg/kg/injection 88.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 28.0 mg/kg/injection 95.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 28.0 mg/kg/injection 97.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 28.0 mg/kg/injection 94.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 28.0 mg/kg/injection 107.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 42.0 mg/kg/injection 103.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 50.0 mg/kg/injection 91.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 56.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 56.0 mg/kg/injection 97.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 56.0 mg/kg/injection 93.0 Experiment continued until the death of all animals; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX Z (ip) mean survival time carboxymethylcellulose (CMC) 100.0 mg/kg/injection 91.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)