In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia resistant to L-Alanosine; NSC 153353 (intraperitoneal) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time alkali diluted with saline 9.38 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 18.8 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 20.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 37.5 mg/kg/injection 94.0 Antitumor endpoint evaluated on day 30; 07/08 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 75.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 80.0 mg/kg/injection 106.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 150.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 03/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time alkali diluted with saline 28.13 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 56.25 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 112.5 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 225.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 450.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 02/08 animals surviving on day 5