In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia resistant to Methotrexate; NSC 740 (intraperitoneal) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 50.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 60.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5