In Vivo Screening Data Summary

NCI In Vivo Screening Data

P329 Reticulum Cell Sarcoma (intraperitoneal) in DBA/2 mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (ip) median survival time alkali diluted with saline 5.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 2; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 10.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 2; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 20.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 2; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 2; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time alkali diluted with saline 80.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 2; 06/06 animals surviving on tox evaluation day (usually day 5)