In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia resistant to Dihydroxy Anthracenedione; NSC 299195 (intraperitoneal) in CD2F1 (CDF1) mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) median survival time saline 13.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time saline 21.6 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time saline 21.6 mg/kg/injection 160.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time saline 36.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time saline 36.0 mg/kg/injection 156.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection 116.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection 226.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time saline 100.0 mg/kg/injection 134.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time saline 100.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 45; 08/08 animals surviving on day 5