In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice

NSC 114781
CAS 27973-72-4
Pederin; Pederine; 2H-Puran-2-acetamide, N-[[6-(2,3-dimethoxypropyl)tetrahydro-4-hydroxy-5,5- dimethyl-2H-pyran-2-yl]tetrahydro-.alpha.-hydroxy-2- methoxy-5,6-dimethyl-4-methylene-, [2S-[2.alpha.[R*[R* (2S*,5S*,6S*)]],4.beta.,6.beta.(R*)]]-

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 6.2 micrograms/kg/injection 153.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 6.25 micrograms/kg/injection 142.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 micrograms/kg/injection 152.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 12.5 micrograms/kg/injection 126.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 micrograms/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 micrograms/kg/injection 161.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 micrograms/kg/injection 162.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 micrograms/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 micrograms/kg/injection 152.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 micrograms/kg/injection 147.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 micrograms/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 00/06 animals surviving on day 5
Q01DX005 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 micrograms/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 00/06 animals surviving on day 5