In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice

NSC 169105
CAS 62-31-7
Dopamine hydrochloride; P 498; Dynatra

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX009 (ip) median survival time saline 1.5 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 1.5 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 15.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 15.0 mg/kg/injection 99.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 25.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 50.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 50.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 100.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 100.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 150.0 mg/kg/injection 123.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 150.0 mg/kg/injection 140.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 150.0 mg/kg/injection 129.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 200.0 mg/kg/injection 115.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 200.0 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 300.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 300.0 mg/kg/injection 140.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 300.0 mg/kg/injection 137.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 400.0 mg/kg/injection 99.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 400.0 mg/kg/injection 121.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 600.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 03/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 600.0 mg/kg/injection 138.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 600.0 mg/kg/injection 153.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time saline 1200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 02/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 50.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 100.0 mg/kg/injection 83.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 200.0 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 400.0 mg/kg/injection 83.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)