In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia (intraperitoneal) in CD2F1 (CDF1) mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX001 (ip) median survival time saline 250.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX001 (ip) median survival time saline 500.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX001 (ip) median survival time saline 500.0 mg/kg/injection 125.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX001 (ip) median survival time saline 1000.0 mg/kg/injection 130.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX001 (ip) median survival time saline 1000.0 mg/kg/injection 99.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX001 (ip) median survival time saline 2000.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on day 5
Q01DX001 (ip) median survival time saline 2000.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on day 5
Q01DX001 (ip) median survival time other 40.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time other 80.0 mg/kg/injection 135.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time other 160.0 mg/kg/injection 127.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time other 320.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time other 640.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time alkali diluted with saline 150.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 5; 08/09 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time alkali diluted with saline 150.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 5; 08/09 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time alkali diluted with saline 200.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 5; 08/09 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time alkali diluted with saline 200.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 5; 08/09 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time alkali diluted with saline 250.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 5; 04/07 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time alkali diluted with saline 250.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 5; 02/06 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (ip) median survival time alkali diluted with saline 300.0 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 5; 04/07 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (iv) median survival time other 40.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (iv) median survival time other 80.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (iv) median survival time other 160.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (iv) median survival time other 320.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX001 (iv) median survival time other 640.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 30; 04/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time saline 50.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time saline 100.0 mg/kg/injection 140.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time saline 100.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time saline 100.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time saline 200.0 mg/kg/injection 124.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time saline 200.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time saline 200.0 mg/kg/injection 115.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time saline 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 04/06 animals surviving on day 5
Q01DX005 (ip) median survival time saline 400.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on day 5
Q01DX005 (ip) median survival time saline 400.0 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on day 5
Q01DX005 (ip) median survival time other 20.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time other 20.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time other 40.0 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time other 40.0 mg/kg/injection 119.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time other 80.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time other 80.0 mg/kg/injection 128.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time other 160.0 mg/kg/injection 112.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time other 160.0 mg/kg/injection 108.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX005 (ip) median survival time alkali diluted with saline 20.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 25.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 119.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 50.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 80.0 mg/kg/injection 120.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 100.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 45; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 160.0 mg/kg/injection 142.0 Antitumor endpoint evaluated on day 45; 05/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with saline 200.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 45; 00/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with water 25.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with water 50.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with water 100.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX005 (ip) median survival time alkali diluted with water 200.0 mg/kg/injection 86.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 25.0 mg/kg/injection 115.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 50.0 mg/kg/injection 123.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 100.0 mg/kg/injection 136.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 200.0 mg/kg/injection 125.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 400.0 mg/kg/injection 115.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 20.0 mg/kg/injection 122.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 20.0 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 20.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 20.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 20.0 mg/kg/injection 106.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 20.0 mg/kg/injection 109.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 20.0 mg/kg/injection 106.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 40.0 mg/kg/injection 103.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 40.0 mg/kg/injection 134.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 40.0 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 40.0 mg/kg/injection 96.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 40.0 mg/kg/injection 106.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 40.0 mg/kg/injection 93.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 40.0 mg/kg/injection 115.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 80.0 mg/kg/injection 121.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 80.0 mg/kg/injection 146.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 80.0 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 80.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 80.0 mg/kg/injection 120.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 80.0 mg/kg/injection 92.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 80.0 mg/kg/injection 116.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 160.0 mg/kg/injection 129.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 160.0 mg/kg/injection 134.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 04/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 04/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time other 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 9.38 mg/kg/injection 111.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 18.8 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 20.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 37.5 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 97.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 40.0 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 50.0 mg/kg/injection 99.0 Antitumor endpoint evaluated on day 60; 09/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 50.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 5; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 60.0 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 60; 10/10 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 60.0 mg/kg/injection 113.0 Antitumor endpoint evaluated on day 5; 09/09 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 75.0 mg/kg/injection 117.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 80.0 mg/kg/injection 95.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with saline 150.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with saline 160.0 mg/kg/injection 106.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX009 (ip) median survival time alkali diluted with water 20.0 mg/kg/injection 118.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with water 40.0 mg/kg/injection 86.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with water 80.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with water 160.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 04/06 animals surviving on day 5
Q01DX009 (ip) median survival time alkali diluted with water 320.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 00/06 animals surviving on day 5
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 37.5 mg/kg/injection 121.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 75.0 mg/kg/injection 117.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 150.0 mg/kg/injection 139.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 300.0 mg/kg/injection 135.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time Klucel (hydroxypropylcellulose) (HPC) 600.0 mg/kg/injection 132.0 Antitumor endpoint evaluated on day 60; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time other 20.0 mg/kg/injection 110.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time other 40.0 mg/kg/injection 117.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time other 80.0 mg/kg/injection 130.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time other 160.0 mg/kg/injection 140.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time other 320.0 mg/kg/injection 137.0 Antitumor endpoint evaluated on day 30; 05/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time alkali diluted with saline 28.13 mg/kg/injection 105.0 Antitumor endpoint evaluated on day 30; 07/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 56.25 mg/kg/injection 99.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 112.5 mg/kg/injection 107.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 225.0 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 30; 08/08 animals surviving on day 5
Q04DX003 (ip) median survival time alkali diluted with saline 450.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 30; 03/08 animals surviving on day 5
Q04DX003 (iv) median survival time other 20.0 mg/kg/injection 116.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (iv) median survival time other 40.0 mg/kg/injection 99.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (iv) median survival time other 80.0 mg/kg/injection 104.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (iv) median survival time other 160.0 mg/kg/injection 138.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (iv) median survival time other 320.0 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 30; 06/06 animals surviving on tox evaluation day (usually day 5)