In Vivo Screening Data Summary

NCI In Vivo Screening Data

P388 Leukemia resistant to Vincristine; NSC 67574 (intraperitoneal) in B6D2F1 (BDF1) mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX010 (ip) median survival time saline 2.5 mg/kg/injection 155.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time saline 5.0 mg/kg/injection 140.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time saline 5.0 mg/kg/injection 135.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time saline 10.0 mg/kg/injection 140.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time saline 10.0 mg/kg/injection 200.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time saline 20.0 mg/kg/injection 116.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time saline 20.0 mg/kg/injection 235.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX010 (ip) median survival time saline 40.0 mg/kg/injection 0.0 Experiment continued until the death of all animals; 06/06 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 21.6 mg/kg/injection 154.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 36.0 mg/kg/injection 188.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 60.0 mg/kg/injection 252.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)
Q04DX003 (ip) median survival time saline 100.0 mg/kg/injection 270.0 Antitumor endpoint evaluated on day 60; 08/08 animals surviving on tox evaluation day (usually day 5)