In Vivo Screening Data Summary

NCI In Vivo Screening Data

Sarcoma 180 (subcutaneous) in Swiss mice

NSC 19893
CAS 51-21-8
Fluorouracil; Efudex; 5-FU

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 4.7 mg/kg/injection 66.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 4.7 mg/kg/injection 116.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 9.5 mg/kg/injection 44.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 9.5 mg/kg/injection 98.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 15.2 mg/kg/injection 89.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 15.2 mg/kg/injection 73.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 19.0 mg/kg/injection 66.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 19.0 mg/kg/injection 67.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 19.0 mg/kg/injection 70.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 19.0 mg/kg/injection 82.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 25.3 mg/kg/injection 76.0 Antitumor endpoint evaluated on day 8; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 25.33 mg/kg/injection 53.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 38.0 mg/kg/injection 29.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 38.0 mg/kg/injection 1.0 Antitumor endpoint evaluated on day 8; 08/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 38.0 mg/kg/injection 16.0 Antitumor endpoint evaluated on day 8; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 38.0 mg/kg/injection 64.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 3.12 mg/kg/injection 83.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 6.25 mg/kg/injection 100.0 Antitumor endpoint evaluated on day 8; 05/06 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 6.3 mg/kg/injection 83.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 9.5 mg/kg/injection 48.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.5 mg/kg/injection 90.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 12.66 mg/kg/injection 39.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 19.0 mg/kg/injection 2.0 Antitumor endpoint evaluated on day 8; 09/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 25.0 mg/kg/injection 25.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)