In Vivo Screening Data Summary

NCI In Vivo Screening Data

Sarcoma 180 (subcutaneous) in Swiss mice

NSC 755
CAS 50-44-2
Mercaptopurine; 6-Purinethiol; 6-Mercaptopurine

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 10.4 mg/kg/injection 51.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 13.0 mg/kg/injection 66.0 Antitumor endpoint evaluated on day 8; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 14.5 mg/kg/injection 83.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 14.5 mg/kg/injection 73.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 17.3 mg/kg/injection 51.0 Antitumor endpoint evaluated on day 8; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 19.0 mg/kg/injection 72.0 Antitumor endpoint evaluated on day 8; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 23.2 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 8; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 26.0 mg/kg/injection 36.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 29.0 mg/kg/injection 45.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 29.0 mg/kg/injection 64.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 29.0 mg/kg/injection 42.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 29.0 mg/kg/injection 65.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 38.6 mg/kg/injection 36.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 43.5 mg/kg/injection 27.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 43.5 mg/kg/injection 47.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 44.0 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 58.0 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 58.0 mg/kg/injection 14.0 Antitumor endpoint evaluated on day 8; 09/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 58.0 mg/kg/injection 21.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 66.0 mg/kg/injection 34.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 100.0 mg/kg/injection 24.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight carboxymethylcellulose (CMC) 150.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 8; 00/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight other 7.5 mg/kg/injection 102.0 Antitumor endpoint evaluated on day 8; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight other 15.0 mg/kg/injection 101.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight other 30.0 mg/kg/injection 78.0 Antitumor endpoint evaluated on day 8; 04/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight other 60.0 mg/kg/injection 47.0 Antitumor endpoint evaluated on day 8; 04/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight other 60.0 mg/kg/injection 33.0 Antitumor endpoint evaluated on day 8; 05/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight other 120.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 8; 01/06 animals surviving on tox evaluation day (usually day 5)
Q01DX007 (ip) mean tumor weight other 240.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 8; 00/06 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 3.25 mg/kg/injection 62.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 3.62 mg/kg/injection 83.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 6.5 mg/kg/injection 61.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 7.25 mg/kg/injection 56.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 13.0 mg/kg/injection 28.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 14.5 mg/kg/injection 48.0 Antitumor endpoint evaluated on day 8; 09/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 26.0 mg/kg/injection 32.0 Antitumor endpoint evaluated on day 8; 10/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight carboxymethylcellulose (CMC) 29.0 mg/kg/injection 20.0 Antitumor endpoint evaluated on day 8; 09/10 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight methylcellulose (MC) 15.0 mg/kg/injection 60.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight methylcellulose (MC) 25.0 mg/kg/injection 55.0 Antitumor endpoint evaluated on day 8; 05/06 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight methylcellulose (MC) 37.5 mg/kg/injection 34.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)
Q#A X014 (ip) mean tumor weight methylcellulose (MC) 50.0 mg/kg/injection 14.0 Antitumor endpoint evaluated on day 8; 06/06 animals surviving on tox evaluation day (usually day 5)