In Vivo Screening Data Summary

NCI In Vivo Screening Data

TE-671 Human Meduloblastoma (intrarenal inoculation) in NU/NU BALB/C (nude) mice

NSC 3088
CAS 305-03-3
Chlorambucil; Leukeran; Ambochlorin

Chemical Data
Schedule (route) Endpoint Vehicle Dose Treated/Control (%) Observations
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.0 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 10; 06/06 animals surviving on day 10
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.0 mg/kg/injection 21.0 Antitumor endpoint evaluated on day 12; 05/05 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 12.0 mg/kg/injection 29.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 18.0 mg/kg/injection 49.0 Antitumor endpoint evaluated on day 10; 06/06 animals surviving on day 10
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 18.0 mg/kg/injection 7.0 Antitumor endpoint evaluated on day 12; 05/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 18.0 mg/kg/injection 10.0 Antitumor endpoint evaluated on day 12; 06/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 27.0 mg/kg/injection 38.0 Antitumor endpoint evaluated on day 10; 05/06 animals surviving on day 10
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 27.0 mg/kg/injection 3.0 Antitumor endpoint evaluated on day 12; 05/06 animals surviving on day 12
Q04DX003 (ip) mean tumor weight change Klucel (hydroxypropylcellulose) (HPC) 27.0 mg/kg/injection 0.0 Antitumor endpoint evaluated on day 12; 03/05 animals surviving on day 12