Skip to Content
Developmental Therapeutics Program (DTP)
Last Updated: 04/02/15

David Evans, Ph.D.

Dr. David Evans joined MPB as head of the Target Validation and Screening Laboratory (TVSL) from Emerald Biostructures. Dr. Evans has expertise in robotics and automation for screening (building HTS platforms at Serono, TGEN, Dharmacon and Sirnaomics) including use of High Content screening (GE Incell 1000 and Thermo ArrayScan instruments) and has been involved in development of standard cell based, enzyme and protein-protein screens for high throughput chemical screens. Dr. Evans is leading the TVSL in screening the sarcoma and small cell lung cancer cell lines upon exposure to single drug and combinations.

REFERENCES

  1. Brito, S., Xu., J., Simonenko, V., Lu, P., Ghias, A., and Evans, DM “2-dimensional siRNA screens identify adjunct targets to improve RNAi therapeutic efficacy in Breast cancer” (manuscript on hold pending IP filing).
  2. Brito, S., Xu., J., Simonenko, V., Lu, P., Ghias, A., and Evans, DM “Combination siRNA and small molecule screen identifies adjunct target to improve therapeutic efficacy in Breast cancer” (manuscript on hold pending IP filing).
  3. Ge, Q., JJ Xu, DM Evans, HH Yang and PY. Lu (2009), “Leveraging Therapeutic Potential of Multi-targeted siRNA Inhibitors."” Future Medicinal Chemistry, Invited Perspectives Vol. 1, No.9, Pages 1671-1681
  4. Ge Q, DM Evans, JJ. Xu, HH.Yang and PY. Lu (2009) “Pulmonary Delivery of Small Interfering RNA for Novel Therapeutics.” Delivery Technologies for Biopharmaceuticals, John Wiley & Sons, Ltd. England.
  5. Evans, D.M., Azorsa, DO and Mousses, S. (2005) “Genome scale cytometry: High content analysis for high throughput RNAi phenotype profiling” Drug Discovery Today: Technologies 2(2), 141-147.
  6. Evans, D.M., and Herman, L. (1997) “Identification of ligands with high affinity for the sugar-binding site of a lectin from a large synthetic combinatorial peptide library” J. Biomolecular Screening 2(4): 225-233
  7. Evans, D.M., McGuinness, B.M., Williams, K.P., Tarr, G., and Jindal, S. (1996a) “Rapid screening of soluble synthetic peptide combinatorial libraries using perfusionbased affinity selection.” Nature/Biotechnology 14; 506-508
  8. Williams, K.P., Evans, D.M., Rosenberg, S. and Jindal, S. (1996b) “Use of a peptide library to characterize differential peptide binding specificities of bacterial and mammalian Hsp70. Techniques in Protein Chemistry VII.

About the Branch Chief

Dr. Mary K. Wolpert, Ph.D. Dr. Beverly A. Teicher PhD is Chief of the Molecular Pharmaco-logy Branch at NCI, a position that she assumed in early 2011. One focus of the Molecular Pharmacology Branch is target and drug discovery for rare and recalcitrant cancers such as sarcoma and small cell lung cancer. Dr. Teicher completed a PhD in Bioorganic Chemistry at the Johns Hopkins University and postdoctoral training at Yale University School of Medicine. More…