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Developmental Therapeutics Program (DTP)
Last Updated: 04/02/15

TPB Publications

1994 Abstracts/Presentations

  1. Tomaszewski, J.E., 1994. Safety and Toxicity Evaluation of Recombinant and Synthetic Vaccine Products: The NCI Experience. BioEast 94, Session 5D, p 35. Washington, D.C.
  2. Agbaria, R., H. Ford, Jr., J.A. Kelley, A. Koester, V. Moore, C.R. Hassler, J.E. Tomaszewski and S.J. Donohue, 1994. Continuous Infusion of Cyclopentenyl Cytosine (NSC-375575) in Beagle Dogs with Hemodynamic and Pharmacologic Monitoring. [Abstract No. 2752]. Proc. Amer. Assoc. Cancer Res., 35, 461.
  3. Benvenuto, J.A., L.A. Zwelling, W.N. Hittelman, W. Plunkett, D. Farquhar and R.A. Newman, 1994. Preclinical Pharmacology Studies of Penclomedine (NSC 338720), [Abstract No. 2303]. Proc. Amer. Assoc. Cancer Res., 35, 386.
  4. Bigelow, J., L. Chrin, P. Horton, L. Mathews and J. McCormack, 1994. Analytical and Pharmacokinetic Studies of a Quinocarmycin Derivative, [Abstract No. 2545]. Proc. Amer. Assoc. Cancer Res., 35, 427.
  5. Bigelow, J., L. Mathews, L. Chrin, P. Horton and J. McCormack, 1994. Analytical Studies and Murine Pharmacokinetics of Cosalane, [Abstract No. 2546]. Proc. Amer. Assoc. Cancer Res., 35, 427.
  6. Egorin, M.J., D.M. Rosen, M.A. Simon, M.F. Ballesteros, E. Dixon and S.S. Pan, 1994. Cellular Accumulation of Chloroquinoxaline Sulfonamide (CQS), [Abstract No. 2334]. Proc. Amer. Assoc. Cancer Res., 35, 392.
  7. Egorin, M.J., Z.M. Yuan, D.L. Sentz, N.D. Eddington and J.L. Eiseman, 1994. Plasma Pharmacokinetics (pk) in CD2F1 Mice of the Polyamine Analog (BE-4444) (NSC D640506), [Abstract No. 2557]. Proc. Amer. Assoc. Cancer Res., 35, 429.
  8. Evans, E., R. Kovatch, R. Lopez, J. Baker, B. Mowry, D. Smith, D. Arneson, R. Gatz, M. McDermott and J.E. Tomaszewski, 1994. Five Daily Dose Toxicity of Bizelesin (NSC-615291) in Fischer 344 Rats and Beagle Dogs. [Abstract No. 2750]. Proc. Amer. Assoc. Cancer Res., 35, 461.
  9. Hill, J.R., J.E. Schindler-Horvat, R.C. Baldwin, J.T. MacGregor, B.L. Osborn, S.J. Donohue and C.A. Tyson, 1994. Toxicity of Ecteinascidin 729 (NSC-638718) in CD2F1 Mice and Beagle Dogs, [Abstract No. 2789]. Proc. Amer. Assoc. Cancer Res., 35, 467.
  10. May, R.D., M.J. Murphy, Jr., C.L. Erickson-Miller, J.E. Tomaszewski, B.L. Osborn and J.G. Page, 1994. Myelotoxicity Evaluation of Dolastatin 10 (NSC-376128) and Swainsonine (NSC-614553) Using Murine, Canine and Human In Vitro CFUGM Assays. [Abstract No. 2398]. Proc. Amer. Assoc. Cancer Res., 35, 402.
  11. Newman, R.A., M. Costa and A. Fuentes, 1994. Analytical Assay Development for Costatolide (NSC 661122) and 7,8-Dihydrocostatolide (NSC 661123), Potential Anti-HIV Agents, [Abstract No. 2526]. Proc. Amer. Assoc. Cancer Res., 35, 424.
  12. Placke, M.E., D.C. Emmerling, M.E. Lynch, S.W. Graves, P.J. Tosca, J.T. Yarrington and J.E. Tomaszewski, 1994. Toxicity of Protease Inhibitor KNI-272 in Rats and Dogs Following Continuous Intravenous Infusion or Repeated IV Treatment. [Abstract No. 2751]. Proc. Amer. Assoc. Cancer Res., 35, 461.
  13. Placke, M.E., R.R. Moutvic, A.W. Singer, L.H. Pai, Q-c Wang, I. Pastan and J.E. Tomaszewski, 1994. Pharmacokinetics and Toxicity Evaluations of the Recombinant Immunotoxin LMB-7 [B3(Fv)-PE38] in Cynomolgus Monkeys. [Abstract No. 2413]. Proc. Amer. Assoc. Cancer Res., 35, 405.
  14. Page, J.G., H.D. Giles, S.L. Gerson, A.C. Smith and J.E. Tomaszewski, 1994. Preclinical Toxicity Study of O6-Benzylguanine (NSC-637037) and BCNU (Carmustine, NSC-409962) in Male and Female Beagle Dogs. [Abstract No.1952]. Proc. Amer. Assoc. Cancer Res., 35, 328.
  15. Reid, J.M., D.L. Walker, S. Naylor, L.H. Benson and M.M. Ames, 1994. Murine Metabolism of Pyrazoloacridine (NSC-366140): Identification and Cytotoxicity of the Urinary Metabolites 9-Desmethylpyrazoloacridine and pyrazoloacridine N-Oxide, [Abstract No. 2512]. Proc. Amer. Assoc. Cancer Res., 35, 421.
  16. Rodman, L.E., H.D. Giles, J.E. Tomaszewski, A.C. Smith, B.L. Osborn and J.G. Page, 1994. Preclinical Toxicology Study of O6-Benzylguanine (NSC-637037) and 1,3-Bis(2-chloroethyl)-1-nitrosourea (NSC-409962) in Mice. [Abstract No. 1954]. Proc. Amer. Assoc. Cancer Res., 35, 328.
  17. Rogers, T.S., L.E. Rodman, J.E. Tomaszewski, B.L. Osborn and J.G. Page, 1994. Preclinical Toxicology and Pharmacokinetic Studies of O6-Benzyl-guanine (NSC-637037) in Mice and Dogs. [Abstract No. 1953]. Proc. Amer. Assoc. Cancer Res., 35, 328.
  18. Schindler-Horvat, J.E., J.R. Hill, S.J. Donohue, B.L. Osborn and C.A. Tyson, 1994. Species Comparison of Toxicity of Dolastatin 10 in CD2F1 Mice and Beagle Dogs, [Abstract No. 2790]. Proc. Amer. Assoc. Cancer Res., 35, 468.
  19. Smith, A.C., L. Rubinstein, A. Koutsoukos, M. Christian, C.K. Grieshaber, J.E. Tomaszewski and M.R. Grever, 1994. Evaluation of Preclinical Toxicity Models for Phase I Clinical Trials of Anticancer Drugs. [Abstract No. 2741]. Proc. Amer. Assoc. Cancer Res., 35, 459.
  20. Walker, D.L., J.M. Reid and M.M. Ames, 1994. Preclinical Pharmacology of the Potent Marine Natural Product, Ecteinascidin 729 (NSC-638718), [Abstract No. 2511]. Proc. Amer. Assoc. Cancer Res., 35, 421.
  21. Yuan, Z., J. Eisman, K. Plaisance, D. Sentz, S. Bigora, M. Fossler, D. Young and M. Egorin, 1994. Plasma Pharmacokinetics (PK) of Butyrate after the Administration of Tributyrin & Na Butyrate to Mice & Rats, [Abstract No. 2556]. Proc. Amer. Assoc. Cancer Res., 35, 424.
  22. Garg, A., J.E. Tomaszewski, E. Barbera-Guillem and M.J. Murphy, Jr., 1994. In Vitro Bone Marrow Toxicity of the Antineoplastic Drug, Bizelesin (NSC-615921). ISEH Abstract No. 133. 23rd Annual Meeting, International Society for Experimental Hematology. Minneapolis, MN.
  23. Trang, J.M., L.E. Rodman, J.F. Martin, A.C. Smith, J.E. Tomaszewski and J.G. Page, 1994. Pharmacokinetics and Dose Range-Finding of O6-Benzylguanine (NSC-637037) in Beagle Dogs Following Single-Dose IV Administration. American Association of Pharmaceutical Scientists (AAPS) Meeting.
  24. Trang, J.M., L.E. Rodman, J.F. Martin, A.C. Smith, J.E. Tomaszewski and J.G. Page, 1994. Pharmacokinetics of O6-Benzylguanine (O6BG) in Combination with 1,3-Bis(2-Chloroethyl)-1-nitrosourea (BCNU) in Beagle Dogs. American Association of Pharmaceutical Scientists (AAPS) Meeting.
  25. Garg, A., J.E. Tomaszewski, E. Barbera-Guillem and M.J. Murphy, Jr., 1994. In Vitro Bone Marrow Toxicity of Flavopiridol (NSC-649890) to Human, Canine and Murine Hematopoietic Progenitor Cells. 36th Annual Meeting, American Society of Hematology. Nashville, TN.
  26. Volpe, D.A., J.E. Tomaszewski, R.E. Parchment, A. Garg, K.P. Flora, M.J. Murphy and C.K. Grieshaber, 1994. Myelotoxic Effects of Bizelesin to Human, Canine and Murine Myeloid Progenitor Cells In Vitro. FDA Science Forum. Washington, DC.
  27. Fukazawa, T., N. Takeuchi, N. Fujisawa, N. Hattori, T. Mimoto, S. Abe, K. Yuki, Y. Kiso, J. Tomaszewski, H. Hayashi and H. Mitsuya, 1994. KNI-272: A Potent HIV Protease Inhibitor Exhibiting a Favorable Oral Bioavailability in Beagle Dogs. [Abstract No. PB0841, p. 207]. Tenth International Conference on AIDS. Yokohama, Japan.

About the Branch Chief

For information regarding the TPB, please contact Dr. Jerry M. Collins, Associate Director, collinsje@mail.nih.gov