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Developmental Therapeutics Program (DTP)
Last Updated: 04/02/15

TPB Publications

2008 Publications

  1. Beumer, J. H., J.L. Eiseman, R.A. Parise, E. Joseph, J.M. Covey, & M.J. Egorin, 2008. Modulation of Gemcitabine, 2?,2?-Difluoro-2?- deoxycytidine) Pharmacokinetics, Metabolism, and Bioavailability in Mice by 3,4,5,6-T. Clin. Cancer Res., 14, 3529-3535.
  2. Beumer, J. H., J.L. Eiseman, R.A. Parise, J.A. Florian, Jr., E. Joseph, E., D.Z. D'Argenio, et al., 2008. Plasma Pharmacokinetics and Oral Bioavailability of 3,4,5,6- Tetrahydrouridine, a Cytidine Deaminase Inhibitor, in Mice. Cancer Chemother. Pharmacol., 62, 457-464.
  3. Horn, T.L., J.B. Harder, W.D. Johnson, P.T. Curry, R.E. Parchment, R.L. Morrissey, P.W. Mellick, K.A. Calis, P.W. Gold, K.C. Rice, C. Contoreggi, D.S. Charney, G. Cizza, E.R. Glaze, J.E. Tomaszewski, D.L. McCormick, 2008. Integration of in vivo and in vitro approaches to characterize the toxicity of Antalarmin, a corticotrophin-releasing hormone receptor antagonist. Toxicology, 248(1), 8-17
  4. Jia, L., Coward, L.C. Kerstner-Wood, Gorman, G., Noker, Kitada S, Pellecchia M P., Reed, J.C. 2008. Comparison of pharmacokinetic and metabolic profiling among gossypol, apogossypol and apogossypol hexaacetate. Cancer Chemotherapy Pharmacol. 61: 63-73.
  5. Jia, L., Noker, P.E., Piazza, G.A., Leuschner, C., Hansel, W., Gorman, G.S., Coward, L.U., Tomaszewski, J. 2008. Pharmacokinetics and Pharmacodynamics of Phor21-?CG(ala), a lytic peptide conjugate. J. Pharm. Pharmacol. 60:1441-48.
  6. Jia L, K. Schweikart K, J. Tomaszewski, J.G. Page, P.E. Noker, S.A. Buhrow , J.M.Reid, M.M. Ames, and D.H. Munn, 2008. Toxicology and pharmacokinetics of 1-methyl-D-tryptophan: absence of toxicity due to saturating absorption. Food Chem Toxicol 46:203-211.
  7. Kitada, S., Kress, C.L., Krajewska, M., Jia, L., Pellecchia, M., Reed, J.C. 2008. Bcl-2 antagonist ApoGossypol (NSC736630) displays single-agent activity in Bcl-2 transgenic mice and has superior efficacy with less toxicity compared to Gossypol (NSC19048). Blood, 111: 3211 - 3219.
  8. Liu, Z., Y. Zhang, Y.F. Hua, J.M. Covey, D.M. Benbrook, & K.K. Chan, 2008. Metabolism of a Sulfur-containing Heteroarotionoid Antitumor Agent, SHetA2, Using Liquid Chromatography/Tandem Mass Spectrometry. Rapid Comm. Mass Spectrom. 22, 3371-3381.
  9. Parise, R. A., J.H. Beumer, C.O. Kangani, J.L. Holleran, J.L. Eiseman,, N.F. Smith, et al., 2008. Liquid Chromatography-Mass Spectrometric Assay for Quantitation of the Short-chain Fatty Acid, 2,2-Dimethylbutyrate (NSC 741804), in Rat Plasma. J. Chromatog. B, 862, 168-174.

About the Branch Chief

For information regarding the TPB, please contact Dr. Jerry M. Collins, Associate Director,