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Developmental Therapeutics Program (DTP)
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Ku70 component of DNA-dependent protein kinase PRO [primary]

Primary Reference(s):

Ku70 component of DNA-dependent protein kinase PRO

Experiment Id: 33055

Pattern Id: MT1695

Clone number:

GenBank Acc:

Rationale: Ku70 has single-stranded DNA-dependent ATP-dependent helicase activity, and is involved in DNA double-strand break repair and V(D)J recombination.

Investigator(s):

Weinstein, Dr. John

National Cancer Institute

Method: Protein microarrays

Unit: Normalized protein levels (DI25)

Protocol: Reverse-phase protein lysate microarrays with 10 two-fold serial dilutions of protein lysates from each of the 60 cell lines were quantitated for expression of particular proteins using mouse monoclonal antibodies and catalyzed signal amplification, then analyzed using a dose interpolation algorithm.

Target Data:

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Unigene

An experimental system for automatically partitioning GenBank sequences into a non-redundant set of gene-oriented clusters.

Gene

Presents information on official nomenclature, aliases, sequence accession numbers, phenotypes, EC numbers, MIM numbers, UniGene clusters, map information, Gene Ontology annotations, and relevant web sites. Replaces LocusLink.

OMIM

A catalog of human genes and genetic disorders.

PubMed

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CGAP

CGAP provides information on gene expression, SNPs, functional pathways and more in normal, precancerous and cancer cells.

Email questions concerning DTP's molecular targets program to: [Moltarget@mail.nih.gov]

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