COMPARE Introduction

Prediction of Biochemical Mechanism of Action from the In Vitro Antitumor Screen of the National Cancer Institute

Kenneth D. Paull, Ernest Hamel, Louis Malspeis

• Introduction
• Methodology
• Applications
  • Discovery of Novel Compounds with a Particular Mechanism
    • Antitubulin agents
    • Topoisomerase II agents
    • Inosine monophosphate dehydrogenase inhibitors
    • Dihydroorotate dehydrogenase inhibitors
  • Use of Molecular Target Measurements as a COMPARE seed