Inosine monophosphate dehydrogenase inhibitors

Jayaram et al. (83, 84, 85) verified that benzamide riboside (BR) was an inosine monophosphate (IMP) dehydrogenase inhibitor, following demonstration by COMPARE that BR correlated well with tiazofurin and selenazofurin cytoxicity patterns. BR was identified by routine surveillance of screened output by using the standard agent database. The closest match to BR among the standard agents was tiazofurin, with a correlation coefficient of 0.76.

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