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Last Updated: 03/12/21

Selected Publications by Natural Products Branch:

  1. Molecular genomic features associated with in vitro response of the NCI-60 cancer cell line panel to natural products. Krushkal J, Negi S, Yee LM, Evans JR, Grkovic T, Palmisano A, Fang J, Sankaran H, McShane LM, Zhao Y, O'Keefe BR. Mol Oncol. 2021 Feb;15(2):381-406. doi: 10.1002/1878-0261.12849. Epub 2020 Nov 24. PMID: 33169510
  2. Recifin A, Initial Example of the Tyr-Lock Peptide Structural Family, Is a Selective Allosteric Inhibitor of Tyrosyl-DNA Phosphodiesterase I. Krumpe LRH, Wilson BAP, Marchand C, Sunassee SN, Bermingham A, Wang W, Price E, Guszczynski T, Kelley JA, Gustafson KR, Pommier Y, Rosengren KJ, Schroeder CI, O'Keefe BR. J Am Chem Soc. 2020 Dec 16;142(50):21178-21188. doi: 10.1021/jacs.0c10418. Epub 2020 Dec 2. PMID: 33263997
  3. An Integrated Strategy for the Detection, Dereplication, and Identification of DNA-Binding Biomolecules from Complex Natural Product Mixtures. Ma H, Liang H, Cai S, O'Keefe BR, Mooberry SL, Cichewicz RH. J Nat Prod. 2020 Nov 23. doi: 10.1021/acs.jnatprod.0c00946. Online ahead of print. PMID: 33226219
  4. Coibamide A Targets Sec61 to Prevent Biogenesis of Secretory and Membrane Proteins. Tranter D, Paatero AO, Kawaguchi S, Kazemi S, Serrill JD, Kellosalo J, Vogel WK, Richter U, Mattos DR, Wan X, Thornburg CC, Oishi S, McPhail KL, Ishmael JE, Paavilainen VO. ACS Chem Biol. 2020 Aug 21;15(8):2125-2136. doi: 10.1021/acschembio.0c00325. Epub 2020 Jul 20. PMID: 32608972
  5. Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea. Pederson PJ, Cai S, Carver C, Powell DR, Risinger AL, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. J Nat Prod. 2020 Jul 24;83(7):2269-2280. doi: 10.1021/acs.jnatprod.0c00423. Epub 2020 Jul 10. PMID: 3264921
  6. Creating and Screening Natural Product Libraries. Wilson BAP, Thornburg CC, Henrich CJ, Grkovic T, O'Keefe BR. Nat Prod Rep. 2020 Jul 1;37(7):893-918. doi: 10.1039/c9np00068b. Epub 2020 Mar 18. PMID: 32186299
  7. National Cancer Institute (NCI) Program for Natural Products Discovery: Rapid Isolation and Identification of Biologically Active Natural Products from the NCI Prefractionated Library. Grkovic T, Akee RK, Thornburg CC, Trinh SK, Britt JR, Harris MJ, Evans JR, Kang U, Ensel S, Henrich CJ, Gustafson KR, Schneider JP, O'Keefe BR. ACS Chem Biol. 2020 Apr 17;15(4):1104-1114. doi: 10.1021/acschembio.0c00139. Epub 2020 Apr 7. PMID: 32223208
  8. Using the Cancer Dependency Map to Identify the Mechanism of Action of a Cytotoxic Alkenyl Derivative from the Fruit of Choerospondias axillaris. Kil YS, Risinger AL, Petersen CL, Liang H, Grkovic T, O'Keefe BR, Mooberry SL, Cichewicz RH. J Nat Prod. 2020 Mar 27;83(3):584-592. doi: 10.1021/acs.jnatprod.9b00896. Epub 2020 Feb 27. PMID: 32105068
  9. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. Newman DJ, Cragg GM. J Nat Prod. 2020 Mar 27;83(3):770-803. doi: 10.1021/acs.jnatprod.9b01285. Epub 2020 Mar 12. PMID: 32162523
  10. Targeting Protein Translation by Rocaglamide and Didesmethylrocaglamide to Treat MPNST and Other Sarcomas. Chang LS, Oblinger JL, Burns SS, Huang J, Anderson LW, Hollingshead MG, Shen R, Pan L, Agarwal G, Ren Y, Roberts RD, O'Keefe BR, Kinghorn AD, Collins JM. Mol Cancer Ther. 2020 Mar;19(3):731-741. doi: 10.1158/1535-7163.MCT-19-0809. Epub 2019 Dec 17. PMID: 3184829
  11. Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens. Grkovic T, Evans JR, Akee RK, Guo L, Davis M, Jato J, Grothaus PG, Ahalt-Gottholm M, Hollingshead M, Collins JM, Newman DJ, O'Keefe BR. Bioorg Med Chem Lett. 2019 Jan 15;29(2):134-137. doi: 10.1016/j.bmcl.2018.12.019. Epub 2018 Dec 10.PMID: 30553734
  12. India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base. White JD, O'Keefe BR, Sharma J, Javed G, Nukala V, Ganguly A, Khan IA, Kumar NB, Mukhtar H, Pauli GF, Walker L, Sivaram S, Rajaraman P, Trimble EL. J Glob Oncol. 2018 Sep;4:1-10. doi: 10.1200/JGO.17.00099. Epub 2017 Nov 16.PMID: 30241135
  13. NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening. Thornburg CC, Britt JR, Evans JR, Akee RK, Whitt JA, Trinh SK, Harris MJ, Thompson JR, Ewing TL, Shipley SM, Grothaus PG, Newman DJ, Schneider JP, Grkovic T, O'Keefe BR. ACS Chem Biol. 2018 Sep 21;13(9):2484-2497. doi: 10.1021/acschembio.8b00389. Epub 2018 Jun 13.PMID: 29812901
  14. Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species. Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. J Nat Prod. 2018 Aug 24;81(8):1884-1891. doi: 10.1021/acs.jnatprod.8b00411. Epub 2018 Aug 14.PMID: 30106296
  15. Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata. Tsurumi F, Miura Y, Saito Y, Miyake K, Fujie T, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Org Lett. 2018 Apr 20;20(8):2282-2286. doi: 10.1021/acs.orglett.8b00624. Epub 2018 Apr 6.PMID: 29624062
  16. Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa. Aimaiti S, Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. J Org Chem. 2018 Jan 19;83(2):951-963. doi: 10.1021/acs.joc.7b02951. Epub 2018 Jan 10.PMID: 29286245
  17. US National Cancer Institute-China Collaborative Studies on Chinese Medicine and Cancer. Jia L, Lin H, Oppenheim J, Howard OMZ, Li J, Fan H, Zhao Z, Farrar W, Zhang Y, Colburn N, Young MR, Li W, Newman D, O'Keefe BR, Beutler J, Liu J, Hao X, Yang X, Ji T, White JD. J Natl Cancer Inst Monogr. 2017 Nov 1;2017(52):lgx007. doi: 10.1093/jncimonographs/lgx007.PMID: 29140488
  18. Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa. Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. J Nat Prod. 2017 Apr 28;80(4):1065-1072. doi: 10.1021/acs.jnatprod.6b01151. Epub 2017 Mar 14.PMID: 28290698
  19. (-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks. Suzuki Y, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. J Nat Prod. 2017 Jan 27;80(1):220-224. doi: 10.1021/acs.jnatprod.6b01153. Epub 2017 Jan 18.PMID: 28099003
  20. Acetophenone Monomers from Acronychia trifoliolata. Miyake K, Suzuki A, Morita C, Goto M, Newman DJ, O'Keefe BR, Morris-Natschke SL, Lee KH, Nakagawa-Goto K. J Nat Prod. 2016 Nov 23;79(11):2883-2889. doi: 10.1021/acs.jnatprod.6b00645. Epub 2016 Oct 24.PMID: 27797192
  21. Bioactive Macrocycles from Nature. In Macrocycles in Drug Discovery. Newman DJ, Cragg GM. Ed. Levin, J., Royal Society of Chemistry, London, 2015, pp. 1-36.
  22. Natural Products as Pharmaceuticals and Sources for Lead Structures. Newman DJ, Cragg GM, Kingston DGI. In. The Practice of Medicinal Chemistry, 4th Edn. Eds. Aldous, D., Rognan, D., Raboisson, P. and Wermuth, C. Elsevier, Amsterdam, pp.102-138, 2015

About the Branch Chief

Dr. Barry R. O’Keefe Dr. Barry R. O’Keefe received a B.S. in Botany from Michigan State University, and a Ph.D. in Pharmacognosy from the University of Illinois at Chicago in 1993. In 1994 he joined the National Cancer Institute’s Laboratory of Drug Discovery Research and Development to study novel proteins from natural products extracts. More…