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Developmental Therapeutics Program (DTP)
Last Updated: 04/07/15

Selected Publications by
Natural Products Branch:

  1. Kingston, D. G. I. and Newman, D. J.: Natural Products as Anticancer Agents in Natural Products in Chemical Biology. Ed. Civjan, N. Wiley, Hoboken, NJ, 2012, pp. 325-349
  2. Newman, D. J. and Cragg, G. M.: Natural Products as Sources of New Drugs over the 30 Years from 1981 to 2010. J. Nat. Prod., 75:311-335, 2012
  3. Cragg, G. M., Katz, F., Newman, D. J. and Rosenthal, J. The Impact of the United Nations Convention on Biodiversity on Natural Products Research. Nat. Prod. Rep., 29:1407-1423, 2012
  4. Newman, D. J., Cragg, G. M. and Grothaus, P. G.: Drug Discovery in the Ocean. In Encyclopedia of Sustainability Science and Technology. Ed. Meyers, R. A., Springer, 3150-3170, 2012
  5. Cragg, G. M. and Newman, D. J. Natural Products: A Continuing Source of Novel Drug Leads, Biochim. Biophys. Acta., 1830:3670-3695, 2013
  6. Newman, D. J. and Giddings, L-A., Natural Products as Leads to Antitumor Drugs, Phytochem. Revs., 13:123–137, 2013
  7. Ibrahim, M. A., Na, M., Oh, J., Schinazi, R. F., McBrayer, T. R., Whitaker, T., Doerksen, R. J., Newman, D. J., Zachos, L. G. and Hamann, M. T., The significance of endangered and threatened plant natural products in the control of human disease. Proc. Natl. Acad. Sci., USA, 110:16832-16837, 2013
  8. Cragg, G. M., Grothaus, P. G. and Newman, D. J., New Horizons for Old Drugs and Drug Leads. J. Nat. Prod., 2014; DOI: 10.1021/np5000796
  9. Newman, D. J. and Cragg, G. M., Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development, Mar. Drugs,12:255-278, 2014
  10. Newman, D. J. and Cragg, G. M., Natural Products as Drugs and Leads to Drugs: An Introduction and perspective as of the end of 2012. In Natural Products and Drugs, Ed. Hanessian, S., VCH Wiley, 2014, pp. 1-41.
  11. Hassig, C. A., Zeng, F.-Y., Kung, P., Kiankarimi, M., Kim, S., Diaz, P. W., Zhai, D., Welsh, K., Morshedian , S., Su, Y., O’Keefe, B., Newman, D. J., Rusman , Y., Kaur, H., Salomon, C. E., Brown, S. G., Baire, B., Michel, A. R., Hoye, T. R., Francis, S., Georg, G. I., Walters, M. A., Divlianska, D. B., Roth, G. P., Wright, A. E. and Reed, J. C., Ultra High Throughput Screening of Natural Product Extracts to Identify Pro-apoptotic Inhibitors of Bcl-2 Family Proteins. J. Biomol. Screening, 19:1201-1211, 2014.
  12. Beutler, J. A., Cragg, G. M., Iwu, M., Newman, D. J. and Okunji, C. The Experience of the United States National Cancer Institute and National Institutes of Health. In Anticancer Potential of African Plants,Ed. Gurib-Fakim, A., John Wiley Blackwell, 2014, pp. 133-151.
  13. Newman, D. J. and Cragg, G. M., Bioactive Macrocycles from Nature. In Macrocycles in Drug Discovery. Ed. Levin, J., Royal Society of Chemistry, London, 2015, pp. 1-36.
  14. Newman, D. J., Cragg, G. M. and Kingston, D. G. I. Natural Products as Pharmaceuticals and Sources for Lead Structures. In. The Practice of Medicinal Chemistry, 4th Edn. Eds. Aldous, D., Rognan, D., Raboisson, P. and Wermuth, C. Elsevier, Amsterdam, pp.102-138, 2015

About the Branch Chief

Dr. Barry R. O’Keefe Dr. Barry R. O’Keefe received a B.S. in Botany from Michigan State University, and a Ph.D. in Pharmacognosy from the University of Illinois at Chicago in 1993. In 1994 he joined the National Cancer Institute’s Laboratory of Drug Discovery Research and Development to study novel proteins from natural products extracts. More…