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Last Updated: 09/28/19

Selected Publications by Natural Products Branch:

  1. Grkovic, T., Evans, J. R., Akee, R. K., Guo, L., Davis, M., Jato, J., Grothaus, P. G., Ahalt-Gottholm, M., Hollingshead, M., Collins, J. M., Newman, D. J., O'Keefe, B. R.: Erythrofordins D and E, two new cassaine-type diterpenes from Erythrophleum suaveolens. Bioorg. Med. Chem. Lett. 2019 Jan 15;29(2):134-137. doi: 10.1016/j.bmcl.2018.12.019. Epub 2018 Dec 10. PubMed PMID: 30553734; PubMed Central PMCID: PMC6330894.
  2. White, J. D., O'Keefe, B. R., Sharma, J., Javed, G., Nukala,V., Ganguly, A., Khan, I. A., Kumar, N.B., Mukhtar, H., Pauli, G. F., Walker, L., Sivaram, S., Rajaraman, P., Trimble, E. L.: India-United States Dialogue on Traditional Medicine: Toward Collaborative Research and Generation of an Evidence Base. J. Glob. Oncol. 2018 Sep;(4):1-10. doi: 10.1200/JGO.17.00099. Epub 2017 Nov 16. PubMed PMID: 30241135; PubMed Central PMCID: PMC6180779.
  3. Takeuchi, M., Saito, Y., Goto, M., Miyake, K., Newman, D. J., O'Keefe, B. R., Lee, K. H., Nakagawa-Goto, K.: Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species. J. Nat. Prod. 2018 Aug 24;81(8):1884-1891. doi: 10.1021/acs.jnatprod.8b00411. Epub 2018 Aug 14. PubMed PMID: 30106296.
  4. Thornburg, C. C., Britt, J. R., Evans, J. R., Akee, R. K., Whitt, J. A., Trinh, S. K., Harris, M. J., Thompson, J. R., Ewing, T. L., Shipley, S. M., Grothaus, P. G., Newman, D. J., Schneider, J. P., Grkovic, T., O'Keefe, B. R.: NCI Program for Natural Product Discovery: A Publicly-Accessible Library of Natural Product Fractions for High-Throughput Screening. ACS Chem. Biol. 2018 Sep 21;13(9):2484-2497. doi: 10.1021/acschembio.8b00389. Epub 2018 Jun 13. PubMed PMID: 29812901.
  5. Tsurumi, F., Miura, Y., Saito, Y., Miyake, K., Fujie, T., Newman, D. J., O'Keefe, B. R., Lee, K. H., Nakagawa-Goto, K.: Secondary Metabolites, Monoterpene-Polyketides Containing a Spiro[3.5]nonane from Cryptocarya laevigata. Org. Lett. 2018 Apr 20;20(8):2282-2286. doi: 10.1021/acs.orglett.8b00624. Epub 2018 Apr 6. PubMed PMID: 29624062.
  6. Aimaiti, S., Suzuki, A., Saito, Y., Fukuyoshi, S., Goto, M., Miyake, K., Newman, D. J., O'Keefe, B. R., Lee, K. H., Nakagawa-Goto, K.: Corymbulosins I-W, Cytotoxic Clerodane Diterpenes from the Bark of Laetia corymbulosa. J. Org. Chem. 2018 Jan 19;83(2):951-963. doi: 10.1021/acs.joc.7b02951. Epub 2018 Jan 10. PubMed PMID: 29286245.
  7. Jia, L., Lin, H., Oppenheim, J., Howard, O. M. Z., Li, J., Fan, H., Zhao, Z., Farrar, W., Zhang, Y., Colburn, N., Young, M. R., Li, W., Newman, D., O'Keefe, B. R., Beutler, J., Liu, J., Hao, X., Yang, X., Ji, T., White, J. D.: US National Cancer Institute-China Collaborative Studies on Chinese Medicine and Cancer. J. Natl. Cancer Inst. Monogr. 2017 Nov 1;2017(52). doi: 10.1093/jncimonographs/lgx007. PubMed PMID: 29140488; PubMed Central PMCID: PMC6279266.
  8. Suzuki, A., Saito, Y., Fukuyoshi, S., Goto, M., Miyake, K., Newman, D. J., O'Keefe, B. R., Lee, K. H., Nakagawa-Goto, K.: Corymbulosins D-H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa. J. Nat. Prod. 2017 Apr 28;80(4):1065-1072. doi: 10.1021/acs.jnatprod.6b01151. Epub 2017 Mar 14. PubMed PMID: 28290698; PubMed Central PMCID: PMC5516477.
  9. Suzuki, Y., Saito, Y., Goto, M., Newman, D. J., O'Keefe, B. R., Lee, K. H., Nakagawa-Goto, K.: (-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks. J. Nat. Prod. 2017 Jan 27;80(1):220-224. doi: 10.1021/acs.jnatprod.6b01153. Epub 2017 Jan 18. PubMed PMID: 28099003; PubMed Central PMCID: PMC5516478.
  10. Miyake, K., Suzuki, A., Morita, C, Goto M, Newman, D. J., O'Keefe, B. R., Morris-Natschke, S. L., Lee, K. H., Nakagawa-Goto, K.: Acetophenone Monomers from Acronychia trifoliolata. J. Nat. Prod. 2016 Nov 23;79(11):2883-2889. Epub 2016 Oct 24. PubMed PMID: 27797192; PubMed Central PMCID: PMC5154168.
  11. Kingston, D. G. I. and Newman, D. J.: Natural Products as Anticancer Agents in Natural Products in Chemical Biology. Ed. Civjan, N. Wiley, Hoboken, NJ, 2012, pp. 325-349
  12. Newman, D. J. and Cragg, G. M.: Natural Products as Sources of New Drugs over the 30 Years from 1981 to 2010. J. Nat. Prod., 75:311-335, 2012
  13. Cragg, G. M., Katz, F., Newman, D. J. and Rosenthal, J. The Impact of the United Nations Convention on Biodiversity on Natural Products Research. Nat. Prod. Rep., 29:1407-1423, 2012
  14. Newman, D. J., Cragg, G. M. and Grothaus, P. G.: Drug Discovery in the Ocean. In Encyclopedia of Sustainability Science and Technology. Ed. Meyers, R. A., Springer, 3150-3170, 2012
  15. Cragg, G. M. and Newman, D. J. Natural Products: A Continuing Source of Novel Drug Leads, Biochim. Biophys. Acta., 1830:3670-3695, 2013
  16. Newman, D. J. and Giddings, L-A., Natural Products as Leads to Antitumor Drugs, Phytochem. Revs., 13:123–137, 2013
  17. Ibrahim, M. A., Na, M., Oh, J., Schinazi, R. F., McBrayer, T. R., Whitaker, T., Doerksen, R. J., Newman, D. J., Zachos, L. G. and Hamann, M. T., The significance of endangered and threatened plant natural products in the control of human disease. Proc. Natl. Acad. Sci., USA, 110:16832-16837, 2013
  18. Cragg, G. M., Grothaus, P. G. and Newman, D. J., New Horizons for Old Drugs and Drug Leads. J. Nat. Prod., 2014; DOI: 10.1021/np5000796
  19. Newman, D. J. and Cragg, G. M., Marine-Sourced Anti-Cancer and Cancer Pain Control Agents in Clinical and Late Preclinical Development, Mar. Drugs,12:255-278, 2014
  20. Newman, D. J. and Cragg, G. M., Natural Products as Drugs and Leads to Drugs: An Introduction and perspective as of the end of 2012. In Natural Products and Drugs, Ed. Hanessian, S., VCH Wiley, 2014, pp. 1-41.
  21. Hassig, C. A., Zeng, F.-Y., Kung, P., Kiankarimi, M., Kim, S., Diaz, P. W., Zhai, D., Welsh, K., Morshedian , S., Su, Y., O’Keefe, B., Newman, D. J., Rusman , Y., Kaur, H., Salomon, C. E., Brown, S. G., Baire, B., Michel, A. R., Hoye, T. R., Francis, S., Georg, G. I., Walters, M. A., Divlianska, D. B., Roth, G. P., Wright, A. E. and Reed, J. C., Ultra High Throughput Screening of Natural Product Extracts to Identify Pro-apoptotic Inhibitors of Bcl-2 Family Proteins. J. Biomol. Screening, 19:1201-1211, 2014.
  22. Beutler, J. A., Cragg, G. M., Iwu, M., Newman, D. J. and Okunji, C. The Experience of the United States National Cancer Institute and National Institutes of Health. In Anticancer Potential of African Plants,Ed. Gurib-Fakim, A., John Wiley Blackwell, 2014, pp. 133-151.
  23. Newman, D. J. and Cragg, G. M., Bioactive Macrocycles from Nature. In Macrocycles in Drug Discovery. Ed. Levin, J., Royal Society of Chemistry, London, 2015, pp. 1-36.
  24. Newman, D. J., Cragg, G. M. and Kingston, D. G. I. Natural Products as Pharmaceuticals and Sources for Lead Structures. In. The Practice of Medicinal Chemistry, 4th Edn. Eds. Aldous, D., Rognan, D., Raboisson, P. and Wermuth, C. Elsevier, Amsterdam, pp.102-138, 2015

About the Branch Chief

Dr. Barry R. O’Keefe Dr. Barry R. O’Keefe received a B.S. in Botany from Michigan State University, and a Ph.D. in Pharmacognosy from the University of Illinois at Chicago in 1993. In 1994 he joined the National Cancer Institute’s Laboratory of Drug Discovery Research and Development to study novel proteins from natural products extracts. More…